Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Apr 29, 2020 cyclophosphamide is the generic ingredient in five branded drugs marketed by ani pharms inc, cipla, hikma, sti pharma llc, amneal, baxter hlthcare, jiangsu hengrui med, bedford, teva parenteral, and roxane, and is included in sixteen ndas. Additional information is available in the individual branded drug profile pages. Endoxan ciclofosfamida bula do medicamento folhetos. Decrease in the activities of lysosomal enzymes may contribute to the urotoxicity of cyclophosphamide in the rat premila abraham 1, indirani kanakasabapathy 2 and emila sugumar 1. New zealand data sheet endoxan data sheet 1 august 2018 page 5 of 22 baxter healthcare ltd in principle, the fall in the peripheral blood cell and thrombocyte count and the time taken to recover may increase with increasing doses of cyclophosphamide. Order generic for cytoxan cyclophosphamide ciclofosfamida.
White round biconvex sugar coated tablets with a white core. Pdf combined protective effect of zinc oxide nanoparticles. In addition, when given in high doses as a part of a myeloablative. Norwegian researchers have commenced phase ii trials of the anticancer drug cyclophosphamide on mecfs patients led by senior consultant dr oystein fluge and prof olav mella, the team is focusing on nonresponders and those patients who have relapsed after treatment with rituximab, a bcell depleting drug.
If you become pregnant while having endoxan, tell your doctor. Laboratorio baxter medicamento farmaco endoxan composicion. Request pdf on apr 28, 2011, xiaohui huyan and others published immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of balbc. The effects of cyclophosphamide on the prolactin cells of the normal rat maria s. Cyclophosphamide is a cytotoxic drug for the treatment of malignant disease in adults and children. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cyclophosphamide cp, also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As a single agent, it has successfully produced an. Poblador, carmen rojas, antonio raya, joaquin quiralte, jose a. Endoxan cyclophosphamide is a cyclic propylene phosphamide ester of nitrogen mustard. Generic cyclophosphamide inn entry, pharmaceutical patent. Ciclofosfamida indicaciones, dosificacion, presentacion. Neosar, citoxan, genuxal, citofosfana, endoxan estado.
Cyclophosphamide is used to treat breast cancer, lung cancer, leukaemia, lymphoma, and myeloma. Cyclophosphamide fda prescribing information, side. Decrease in the activities of lysosomal enzymes may. Request pdf on apr 28, 2011, xiaohui huyan and others published immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of. Adrian simpson, united states says, if you are looking for a fair deal on medical supplies, idm is something i would seriously recommend.
Immunosuppressive effect of cyclophosphamide on white. C 7 h 1 5 cl 2 n 2 o 2 p marcela rosario fernandez 05jun2007 7. Composicion, indicaciones, presentacion y contraindicaciones. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk e. Immunosuppressive effect of cyclophosphamide on white blood. Craig, united states says, seemed easy to purchase, reasonable prices. The effects of cyclophosphamide on the prolactin cells of the. Both men and women taking endoxan and their partners must use a reliable method of contraception during and for 3 months after receiving endoxan. Cyclophosphamide is an alkylating agent of the nitrogen mustard type. Docetaxel taxotere e ciclofosfamida cytoxan, lidando com efeitos colaterais.
Cyclophosphamide 50 mg tablets by caroline mcdermott at this product is available as the above name but will be referred to as cyclophosphamide throughout the following leaflet. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Endoxan may cause birth defects if either the male or female is being treated with it at the time of conception. Generic cyclophosphamide inn entry, pharmaceutical patent and.
A ciclofosfamida pode aumentar a atividade dos anticoagulantes orais. The effects of cyclophosphamide on the prolactin cells of. Ciclofosfamide universita degli studi dellinsubria. Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. Endoxan ciclofosfamida bula do medicamento folhetos, bulas. Read all of this leaflet carefully before you start taking this medicine. Associada ao alopurinol, ocorre prolongamento da meiavida da ciclofosfamida. Cyclophosphamide therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of acute liver injury. Endoxan poate fi utilizat singur sau in asociere cu alte medicamente. It is best to read this information with our general information about chemotherapy and the type of cancer you have your doctor will talk to you about this treatment and its possible side effects before you agree consent to.
Casares and jose luis lancho alonso department of morphological sciences, human anatomyneuroanatomy section, faculty of medicine, university of cordoba, spain summary. Handle and dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs. As an immune suppressor it is used in nephrotic syndrome. Cyclophosphamide is an alkylating drug indicated for treatment of. If you have any further questions, ask your doctor or pharmacist. To report suspected adverse reactions, contact baxter.
Vials containing 200 mg, 500 mg, and 1 g cyclophosphamide as powder per vial. Internationala a substantei active este ciclofosfamida. Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamideinduced toxicity in testicular histology and sperm parameters in adult wistar rats. Eine trockenstechampulle enthalt 2,8 mg cyclophosphamidmonohydrat entsprechend 200 mg. Caution should be exercised when handling and preparing cyclophosphamide for injection, usp lyophilized powder, or bottles containing cyclophosphamide tablets. Cyclophosphamide for injection, usp cyclophosphamide tablets, usp description cyclophosphamide for injection, usp is a sterile white powder containing.
Genuxal ciclofosfamida monoidratada baxter hospitalar ltda. Ciclofosfamida, neosar, citoxan, genuxal, citofosfana. Each tablet contains cyclophosphamide monohydrate equivalent to 50 mg anhydrous cyclophosphamide. Tablets containing 50 mg cyclophosphamide per tablet pharmacological classification.
Provavel aumento na toxicidade devido a ciclofosfamida. Cyclophosphamide fda prescribing information, side effects. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. What are the generic drug sources for cyclophosphamide and what is the scope of patent protection cyclophosphamide is the generic ingredient in five branded drugs marketed by ani pharms inc, cipla, hikma, sti pharma llc, amneal, baxter hlthcare, jiangsu hengrui med, bedford, teva parenteral, and roxane, and is included in sixteen ndas. It is best to read this information with our general information about chemotherapy and the type of cancer you have. Brian pavey, united states says, idm makes online shopping a pleasure. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Cyclophosphamide is an alkylating agent, and prevents. To report suspected adverse reactions, contact baxter healthcare at 18668882472 or fda at 1800fda1088 or. Sintra business park, zona industrial da abrunheira, edificio 10, 2710089 sintra portugal.
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